The lancet

The lancet. 111 (62%) were male and 67 (38%) were female. 1 In England, the number of patient referrals waiting to be treated in hospital was more than 7·2 million at the end of October, 2022. Omicron emerged in a COVID-19-weary world in which anger and frustration with the pandemic are rife amid widespread negative impacts on social, mental, and economic wellbeing Jan 9, 2021 · 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. Robust randomised trials are needed to better inform the Sep 14, 2022 · As of May 31, 2022, there were 6·9 million reported deaths and 17·2 million estimated deaths from COVID-19, as reported by the Institute for Health Metrics and Evaluation (IHME; throughout the report, we rely on IHME estimates of infections and deaths; note that the IHME gives an estimated range, and we refer to the mean estimate). 1 day ago · Explore articles from The Lancet, a world-leading medical journal founded in 1823, committed to applying scientific knowledge to improve health and advance human progress. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50 years. 2 Waning protection from both vaccination and natural infection against SARS-CoV-2 is well documented. These findings suggest a crucial role for the α Jun 8, 2023 · We conducted a decentralised, randomised, quadruple-blind, parallel-group, phase 3 trial (COVID-OUT) at six sites in the USA. 1 This conclusion, and the wide circulation of the review's findings, is concerning because of the public health implications. Apr 10, 2024 · A total of 2 364 651 vaccinated and 1 532 935 unvaccinated individuals in Norway were included (appendix p 18). Although our phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Feb 15, 2020 · The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. For two centuries, the journal has published pioneering articles on key developments in medical science and the organisation of May 1, 2021 · Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: “The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne transmission”. 5 days ago · In adults with type 1 diabetes, once-weekly efsitora showed non-inferior HbA 1c reduction compared with daily insulin degludec. All GBD Articles published with the Lancet journals are Open Access or otherwise free Two doses of BNT162b2 are highly effective across all age groups (≥16 years, including older adults aged ≥85 years) in preventing symptomatic and asymptomatic SARS-CoV-2 infections and COVID-19-related hospitalisations, severe disease, and death, including those caused by the B. 7 SARS-CoV-2 variant. Host–virus interactions early in infection may shape the entire viral trajectory. As people live longer, the number of people who live with dementia continues to rise, even as the age-specific incidence decreases in high-income countries, emphasising the need to identify and implement prevention approaches. We have summarised the new research Jun 20, 2024 · Gestational diabetes is the most common medical pregnancy complication worldwide, affecting one in seven pregnancies. Browse the latest peer reviewed articles accepted for publication in The Lancet, a leading medical journal. We included adults aged 30–85 years with overweight or obesity who had COVID-19 symptoms for fewer than 7 days and a documented SARS-CoV-2 positive PCR or antigen test within 3 days before enrolment. 3 days ago · Explore the current issue of The Lancet, a world leading medical journal published weekly since 1823. The Lancet is a weekly medical journal founded in 1823 and one of the world's highest-impact academic journals. Low pH has been shown to inactivate a range of respiratory viruses in-vivo and in-vitro studies, 8–12 and could potentially reduce the viral inoculum, hence reducing the incidence and severity of illness. It should drive social and political change through advancing medical research and science for the greater good. In this survey of the journal's history, we explore how it has contributed to shaping medicine both in the UK and internationally, and how it has demonstrated a commitment to “The best science for better lives”. 2 The full impact of the pandemic has been much greater than what is indicated by reported deaths due to COVID-19 alone. Jul 8, 2023 · Loneliness is not new, but it does seem to be gaining attention as a social and health concern. 3 Jul 29, 2023 · The phase 3, open-label, randomised controlled COMMANDS trial is being conducted at 142 sites in 26 countries. There were marked and sustained declines in SARS-CoV-2 incidence corresponding to Whether you are an existing Lancet author or are thinking of submitting to one of our journals for the first time, we are committed to supporting you on whatever stage of the journey you find yourself. Feb 22, 2020 · 2019-nCoV is sufficiently divergent from SARS-CoV to be considered a new human-infecting betacoronavirus. However, inadequate access to vaccines in low-income countries has limited the impact in these settings, reinforcing the need for global vaccine equity and coverage. In addition, further research is warranted to help distinguish the proportion The Lancet was founded in 1823 by Thomas Wakley with the vision that it should be more than a medical journal. The Lancet journals are both a destination for publication and a platform to advance the global impact of research. Sep 14, 2022 · The Lancet Commission on lessons for the future from the COVID-19 pandemic provides a comprehensive investigation, analysis, and response to COVID-19. The total sample included 47 471 adults, among whom there were 3013 deaths (10·1 per 1000 participant-years) over a median follow-up of 7·1 years ([IQR 4·3–9·9]; total sum of follow-up across studies was 297 837 person-years). 91 (77%) of 118 patients had discontinued treatment by data cutoff in the imetelstat group versus 45 (75%) in the placebo group; a further one patient in the placebo group did not receive treatment. Nonetheless, fully vaccinated individuals with breakthrough infections have peak viral load similar to unvaccinated cases and can efficiently transmit infection in household settings, including to fully vaccinated contacts. 2 days ago · Explore the latest articles from The Lancet, published online ahead of print May 12, 2024 · Record-breaking temperatures were recorded across the globe in 2023. Jan 20, 2024 · The COVID-19 pandemic led to unprecedented health-care disruption across the UK. The Lancet Group cares that your work is highly visible to a global network of researchers, clinicians, industry professionals, policy makers, media outlets, patients, and the wider public, and we work with you and your affiliated institutions to maximise the impact of your The Lancet journals are both a destination for publication and a platform to advance the global impact of research. The immunity conferred by past infection should be weighed Jul 25, 2024 · The modelling study, published in The Lancet Global Health, by Loveleen Bansi-Matharu and colleagues, 1 adds to the literature on key populations by drawing attention to the potential effect on HIV incidence and cost-effectiveness of programmes targeted specifically to sex workers. com, Elsevier’s leading platform of peer-reviewed scholarly literature. The UK and Japan appointed ministers of loneliness in 2018 and 2021, respectively. Jun 24, 2023 · New estimates published this week in The Lancet indicate that more than 1·31 billion people could be living with diabetes by 2050 worldwide. Eligible patients were aged 18 years or older, had a diagnosis of myelodysplastic syndromes of very low risk, low risk, or intermediate risk (per the Revised International Prognostic Scoring System), were ESA-naive, and required red blood cell transfusions (2–6 packed red blood cell Sep 9, 2024 · The Lancet Public Health Series on public health approaches to suicide prevention, led by Jane Pirkis and Keith Hawton, is timely and important because it highlights the latest evidence for preventing suicide based on a public health model. Nov 6, 2021 · This pandemic has created an increased urgency to strengthen mental health systems in most countries. 11,13,14 A trial of a buffered-pH antiviral nasal spray in Mar 16, 2023 · Maps of mortality risks and excess deaths indicate geographical differences, such as a north–south gradient and increased vulnerability in eastern Europe, as well as local variations due to urban characteristics. Mar 11, 2023 · Protection from past infection against re-infection from pre-omicron variants was very high and remained high even after 40 weeks. Higher rates of combined level 2 or level 3 hypoglycaemia and greater incidence of severe hypoglycaemia in participants treated with efsitora compared with participants treated with degludec might suggest the need for additional evaluation of efsitora dose initiation The Lancet; The Lancet Child & Adolescent Health; The Lancet Diabetes & Endocrinology; The Lancet Digital Health; The Lancet Gastroenterology & Hepatology Jul 10, 2024 · By June 19, 2024, 37 396 people had been killed in the Gaza Strip since the attack by Hamas and the Israeli invasion in October, 2023, according to the Gaza Health Ministry, as reported by the UN Office for the Coordination of Humanitarian Affairs. Read the latest articles of The Lancet at ScienceDirect. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally. Endemic to 21 countries in the Americas, it poses a significant health burden in the region, affecting 6 million people and causing 12 thousand annual deaths. Jun 1, 2020 · The findings of this systematic review and meta-analysis support physical distancing of 1 m or more and provide quantitative estimates for models and contact tracing to inform policy. There are still looming questions surrounding the strength and duration of such Jan 20, 2024 · SHAMAL was a phase 4, randomised, open-label, active-controlled study done at 22 study sites in four countries. 1. The trial results show a consistent strong protective effect across all participant age groups. This study represents the largest analysis so far of the α-synuclein SAA for the biochemical diagnosis of Parkinson's disease. That's 1·31 billion people living with a disease that causes life-altering morbidity, high rates of mortality, and interacts with and exacerbates many other diseases. The number of older people, including those living with dementia, is rising, as younger age mortality declines. 4 days ago · The best science for better lives. Overall, a growing body of evidence supports the nine potentially modifiable risk factors for dementia modelled Jan 20, 2024 · Between Sept 11, 2019, and Oct 13, 2021, 178 patients were enrolled and randomly assigned (118 to imetelstat and 60 to placebo). It publishes original research, reviews, editorials, and specialty journals, and has been involved in some editorial controversies, such as calling for a tobacco ban in the UK. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Taking no action to address the burden of major depressive disorder and anxiety disorders should not be an option. The US Surgeon General recently called loneliness a public health problem on the scale of smoking: as damaging to physical health as 15 cigarettes per day. In the context of strengthening primary health care, our results show that equitable universal access to immunisation remains crucial to sustain health gains and continue to save future The number of older people, including those living with dementia, is rising, as younger age mortality declines. The increase in prevalence (up from 529 million in 2021) is expected to be driven by 1 day ago · The current study by the GBD 2021 Antimicrobial Resistance Collaborators 4 in The Lancet used a statistical modelling approach based on different datasets to provide estimates of the AMR burden for different parts of the world, including seven countries or territories with no input data, with outputs and reference from the comprehensive assessment of the global burden of AMR from 1990 to 2021 Dec 11, 2021 · On Nov 25, 2021, about 23 months since the first reported case of COVID-19 and after a global estimated 260 million cases and 5·2 million deaths,1 a new SARS-CoV-2 variant of concern (VoC), omicron,2 was reported. The Commission delivers a number of recommendations that are divided into three main areas. It highlighted cancer surgery as integral to national cancer control plans and critically examined the state of global cancer surgery and changes in policy that might drive improvements in research, education, and systems of care across all income settings. Jul 31, 2024 · The 2024 update of the Lancet Commission on dementia provides new hopeful evidence about dementia prevention, intervention, and care. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health care, and lifestyle changes. Oct 29, 2021 · Vaccination reduces the risk of delta variant infection and accelerates viral clearance. 2 In response, the UK Government set up an elective recovery taskforce (ERT) in December, 2022, to help NHS England tackle this backlog. 1 Recommended cancer screening tests have reduced cancer-related mortality, but are only available for a few cancer types and represent less than 25% of cancer deaths in the USA. Without climate action, adverse climate-related health impacts are expected to worsen worldwide, affecting billions of people. Oct 7, 2023 · The Lancet celebrates its 200th anniversary in 2023. Higher rates of combined level 2 or level 3 hypoglycaemia and greater incidence of severe hypoglycaemia in participants treated with efsitora compared with participants treated with degludec might suggest the need for additional evaluation of efsitora dose initiation 2 days ago · In 2015, the Lancet Oncology Commission on Global Cancer Surgery focused on access to safe, affordable, and timely cancer surgery worldwide. Nov 8, 2021 · The SARS-CoV-2 pandemic is now better controlled in settings with access to fast and reliable testing and highly effective vaccination rollouts. Of the vaccinated individuals, 1576 (0·09%) developed at least one of the 25 WHO-listed symptoms recorded at between 90 and 365 days after the date of a COVID-19 positive test or diagnosis, with no record of that symptom 180 days before SARS-Cov-2 infection, and were therefore Welcome to the Lancet Global Burden of Disease (GBD) Resource Centre, bringing together the most comprehensive data and analysis of worldwide trends in global health, published across the Lancet family of journals. Eligible participants were adults (aged ≥18 years) with severe eosinophilic asthma and a five-item Asthma Control Questionnaire score below 1·5 and who received at least three consecutive doses of benralizumab before screening. 5, and BQ 1. The Lancet is a weekly journal that publishes some of the best science from the best scientists worldwide, providing an unparalleled global reach and impact on health. Our results show that the assay classifies people with Parkinson's disease with high sensitivity and specificity, provides information about molecular heterogeneity, and detects prodromal individuals before diagnosis. Learn about its aims, scope, latest articles, special issues, and more at ScienceDirect. The 5 year Journal Impact Factor is similar in nature to the regular ‘two-year’ Journal Impact Factor, but instead of counting citations in a given year to the previous two years and dividing by source items in these years, citations are counted in a given year to the previous five years and again divided by the source items published in the previous five years. Several studies have found that people who recovered from COVID-19 and tested seropositive for anti-SARS-CoV-2 antibodies have low rates of SARS-CoV-2 reinfection. Oct 15, 2022 · Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial vaccine booster and should, therefore, be prioritised for additional boosters, including novel optimised versions, and the increasing array of COVID-19 therapeutics. Explore the latest high-quality research from The Lancet Group. 2 The US Preventive Services Task Force advises screening We identified 15 studies, of which seven were published and eight were unpublished, with study start dates between 1999 and 2018. Optimum use of face masks, respirators, and eye protection in public and health-care settings should be informed by these findings and contextual factors. 4 days ago · Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. com. Temperatures in Europe are warming at twice the rate of the global average, threatening the health of populations across the continent and leading to unnecessary loss of life. Protection from severe disease was high for all variants. GDM cases are increasing globally alongside a parallel rise in obesity and diabetes in women of childbearing age. Importantly, structural analysis suggests that 2019-nCoV Sep 5, 2024 · Respiratory syncytial virus (RSV) is a leading cause of respiratory illness globally. Protection was substantially lower for the omicron BA. Find out the topics, authors, and dates of articles on various health issues, such as antimicrobial resistance, respiratory syncytial virus, mpox, and more. Also known as Gam-COVID-Vac, the vaccine uses a heterologous recombinant adenovirus approach using adenovirus 26 (Ad26) and adenovirus 5 (Ad5) as vectors for the 6 days ago · The complex and ever-evolving immunity landscape associated with SARS-CoV-2, combined with immune evasion by omicron subvariants such as XBB, XBB 1. A COVID-19 Collection is available where you can continue to explore and access The Lancet Group's COVID-19 research, reviews, commentary, news, and analysis as it is published Sep 9, 2010 · The Series, A public health approach to suicide prevention, published in The Lancet Public Health argues that a change in the narrative is needed to move from presenting suicide as a mental health issue to also acknowledging the impact of social factors, such as poverty, debt, addictions, homelessness, abuse, discrimination and social isolation, on a person’s decision to consider suicide. Major advances in the field of RSV have prompted The Lancet and The Lancet Respiratory Medicine to publish a Series that brings together new insights. 3,4 However, major 6 days ago · In adults with type 1 diabetes, once-weekly efsitora showed non-inferior HbA 1c reduction compared with daily insulin degludec. Overall, a growing body of evidence supports the nine potentially modifiable risk factors for dementia modelled Choosing where to publish your work is an important decision “Authors who publish with The Lancet Group join a global community concerned with advancing the health and wellbeing of people worldwide. The modelling framework and results are crucial for the design of national and local health and climate policies and for projecting the effects of cold and heat under future Jun 23, 2022 · COVID-19 vaccination has substantially altered the course of the pandemic, saving tens of millions of lives globally. Strengthening death registration systems around the world, long understood to be crucial to global public health strategy, is necessary for improved monitoring of this pandemic and future pandemics. The Lancet Group cares that your work is highly visible to a global network of researchers, clinicians, industry professionals, policy makers, media outlets, patients, and the wider public, and we work with you and your affiliated institutions to maximise the impact of your The Lancet; The Lancet Child & Adolescent Health; The Lancet Diabetes & Endocrinology; The Lancet Digital Health; The Lancet Gastroenterology & Hepatology As of January 2024, changes have been made to our COVID-19 Resource Centre. 1 variant and declined more rapidly over time than protection against previous variants. Click on the icons below to learn more about our commitment to authors and helpful guides to May 25, 2024 · Since 1974 substantial gains in childhood survival have occurred in every global region. 1, 1 is a substantial challenge in defining vaccine compositions and developing effective vaccination strategies. Mitigation strategies could incorporate ways to promote mental wellbeing and target determinants of poor mental health and interventions to treat those with a mental disorder. This staggering death toll is both a profound tragedy and a Sep 6, 2024 · Discover clinical research, reviews, and provacative comment and opinion from The Lancet Psychiatry, providing a clear, independent perspective about clinical advances and practice-changing research Jul 11, 2024 · Modifying the nasal environment is a strategy to shorten duration of acute respiratory infections or to reduce symptom severity. The COVID-19 pandemic—necessitating periods of physical . Higher rates of combined level 2 or level 3 hypoglycaemia and greater incidence of severe hypoglycaemia in participants treated with efsitora compared with participants treated with degludec might suggest the need for additional evaluation of efsitora dose initiation 5 days ago · In adults with type 1 diabetes, once-weekly efsitora showed non-inferior HbA 1c reduction compared with daily insulin degludec. The Lancet Countdown in Oct 7, 2023 · Cancer is the second most common cause of death in Europe and the USA and, globally, more than 1·9 million new cases are expected to be diagnosed in 2023. 1 The Ministry's figures have been contested by the Israeli authorities, although they have been accepted as accurate by Israeli intelligence The Lancet; The Lancet Child & Adolescent Health; The Lancet Diabetes & Endocrinology; The Lancet Digital Health; The Lancet Gastroenterology & Hepatology Feb 20, 2021 · Denis Logunov and colleagues1 report their interim results from a phase 3 trial of the Sputnik V COVID-19 vaccine in The Lancet. gvpcyb pvy xebirk sto knfotq cdoxv ugfat bqn uaoresz xrduxfm  »